Blastofen 20 mg
Blastofen is used to treat breast cancer that has spread to other parts of the body (metastatic breast cancer), to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients. Blastofen can block the growth of breast cancer. It works by interfering with the effects of estrogen in the breast tissue.
Blastofen is a non-steroid anti-estrogen which competitively inhibits estrogen receptors in the target organs and tumors in them. Mechanism of its action is not completely investigated though it is known that a complex of Blastofen with the receptor and cofactor appears and than it is transferred to the cell nucleus preventing hypertrophy of the cells which depend on regulation by estrogen. The effect of the medication can last several weeks after a single dose.
Blastofen is able to cause ovulation in women, stimulation production of gonadotropic hormones of hypophysis. In men with oligospermia it increases concentration of luteinizing hormone and follicle-stimulating hormone, testosterone and estrogen in the blood serum. Blastofen is used to treat breast cancer in women and in men (especially after castration) and also when it has spread to other parts of the body, kidney cancer, melanomas and sarcomas of the soft tissues with estrogen receptors, cancer of the ovary.
Take Blastofen exactly as recommended by your physician as the dosage depends on your condition. Long treatment (about 2 years) is advised. Take Blastofen with food and a big glass of water as a single dose or divide it in two (taken in the morning and the evening), do not chew or crush them.
Blastofen may increase the possibility of developing endometrial cancer. Patients who are treated with Blastofen should be monitored for any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure.
Blastofen is contradicted in patients with hypersensitivity to this medication and also in women who are threated by coumarin-type anticoagulant therapy or in women with deep vein thrombosis or pulmonary embolus in history, pregnant or breastfeeding women. Cautiousness should be exercised in patients with eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, severe thrombophlebitis, thromboembolism (also in history).
Side effects caused by Blastofen are: hot flashes, nausea, vomiting, weight gain, abnormal menstrual periods.
Blastofen is able to cause abnormalities in liver and blood tests, so regular monitoring of side effects caused by Blastofen is required. If such signs as jaundice and bleeding appear a patient should immediately seek for immediate medical help.